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The FDAs Center for Biologics Evaluation and Research is expecting an influx of cell and gene therapy applications, and in March 2023 established a new super office, the Office of Therapeutic Products, in an attempt to keep up with the demand

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However, it is unclear to what extent the in vitro observations correspond to metabolic and disease processes seen in vivo 12

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In the xylem tissue, the continuous activity of H + ATPase leads to hyperpolarization of the membrane, which in turn limits the efflux of positive ions from the cytosol